What are the epigenetic consequences of maternal folic acid supplementation?

30 April 2014 1 1K Report

Hepatic protein expression in animal models.

Hi,

You might find some answers in the following articles:

Maternal exposure to fluoxetine during gestation and lactation affects the DNA methylation programming of rat's offspring: modulation by folic acid supplementation.

Toffoli LV, Rodrigues GM Jr, Oliveira JF, Silva AS, Moreira EG, Pelosi GG, Gomes MV.

Behav Brain Res. 2014 May 15;265:142-7. doi: 10.1016/j.bbr.2014.02.031. Epub 2014 Feb 28.

Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid.

Barua S, Kuizon S, Chadman KK, Flory MJ, Brown WT, Junaid MA.

Epigenetics Chromatin. 2014 Feb 3;7(1):3. doi: 10.1186/1756-8935-7-3.

Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort.

Bae S, Ulrich CM, Bailey LB, Malysheva O, Brown EC, Maneval DR, Neuhouser ML, Cheng TY, Miller JW, Zheng Y, Xiao L, Hou L, Song X, Buck K, Beresford SA, Caudill MA.

Epigenetics. 2014 Mar;9(3):396-403. doi: 10.4161/epi.27323. Epub 2013 Dec 3.

Nutri-epigenetics ameliorates blood-brain barrier damage and neurodegeneration in hyperhomocysteinemia: role of folic acid.

Kalani A, Kamat PK, Givvimani S, Brown K, Metreveli N, Tyagi SC, Tyagi N.

J Mol Neurosci. 2014 Feb;52(2):202-15.

Nutrition in early life, immune-programming and allergies: the role of epigenetics.

Amarasekera M, Prescott SL, Palmer DJ.

Asian Pac J Allergy Immunol. 2013 Sep;31(3):175-82.

You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring.

Vanhees K, Vonhögen IG, van Schooten FJ, Godschalk RW.

Cell Mol Life Sci. 2014 Jan;71(2):271-85. doi: 10.1007/s00018-013-1427-9. Epub 2013 Jul 27. Review.

High folate gestational and post-weaning diets alter hypothalamic feeding pathways by DNA methylation in Wistar rat offspring.

Cho CE, Sánchez-Hernández D, Reza-López SA, Huot PS, Kim YI, Anderson GH.

Epigenetics. 2013 Jul;8(7):710-9. doi: 10.4161/epi.24948. Epub 2013 May 14.

Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring.

Langie SA, Achterfeldt S, Gorniak JP, Halley-Hogg KJ, Oxley D, van Schooten FJ, Godschalk RW, McKay JA, Mathers JC.

FASEB J. 2013 Aug;27(8):3323-34. doi: 10.1096/fj.12-224121. Epub 2013 Apr 19.

Folate and fetal programming: a play in epigenomics?

Guéant JL, Namour F, Guéant-Rodriguez RM, Daval JL.

Trends Endocrinol Metab. 2013 Jun;24(6):279-89. doi: 10.1016/j.tem.2013.01.010. Epub 2013 Mar 6. Review.

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