The synthesis of sulfated compounds is intricate to achieve and percentage yield of the product is low. The reaction leads to formation of many conjugates thereby making it difficult to isolate sulfated compound from the reaction mixture. Moreover most of sulfated compounds are water soluble compounds, therefore to purify these compounds becomes very difficult. What are the different ways to purify sulfated compounds other then RP-HPLC?
Hi,
I don't know what 'compounds' your're referring to, but could anion exchange be an option?
Good luck!
If your product has high molecular weight just purify it by dialysis. Other way convert its water soluble derivative to insoluble salt form, like Ca salt
Dear Esmat Jalalvandi
,It is interesting, could you please, give more detailed info about crosslinking which might occur during dialysis?
Dialysis should work. If it is high molecular weight compound you can use designer solvents which are selective in action like supercritical fluids or ionic liquids.
Nodirali S. Normakhamatov This is one such polysulfated compound. Kindly check the attached tif file.
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