Which kinds of these cells (HFF or HDF) are better for wound healing research ?
(Human) dermal fibroblasts (HDF) originate from mesenchymal cells and are the main cell type present in skin connective tissue (dermis). They are located in particular, in the dermis and are the main actors of extracellular matrix (ECM) production and homeostasis. Fibroblasts interact with epidermal cells during hair development and in interfollicular skin. Moreover, they play an essential role during cutaneous wound healing and in bioengineering of skin.
In researches, Human Dermal Fibroblasts (NHDF) are isolated form the dermis of juvenile foreskin or adult skin from different locations like the face, the breasts, the abdomen, and the thighs. Those whoe are isolated from the foreskin are specifically labeled Human Foreskin Fibroblasts (HFF).
Such cells then undergo cryopreservation and can be used for wound healing studies and dermatological research to investigate diseases like scleroderma, fibrosarcoma, fibrosis, xeroderma pigmentosum, and histiocytoma. Moreover, fibroblasts are important for cancer research, tissue regeneration, and tissue engineering studies.
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