The idea that there might be a link between the rise in allergic disease and reduced microbial exposure as a result of measures introduced to protect against infection was first proposed in 1989.This so-called hygiene hypothesis, as outlined by Dr David Strachan, proposed that a lower incidence of infection in early childhood could be an explanation for the 20th century rise in atopic diseases.

( Bloomfield SF, Rook GA, Scott EA, Shanahan F, Stanwell-Smith R, Turner P. Time to abandon the hygiene hypothesis: new perspectives on allergic disease, the human microbiome, infectious disease prevention and the role of targeted hygiene. Perspect Public Health. 2016;136:213-24.)

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