I study diabetic tendinopathy and would like to know the reasons for choosing rat animal models over mice when it comes to metabolic syndrome. Your help and discussions are very valuable to me. Thank you.
My vast experience with mice and rats tells me that you can use rats.
(Both mice and rats...).
P.F. Zabrodskii Could you please share your experience showing that rats are better than mice in terms of metabolic syndrome models? Thank you.
I don't think rats are better (rats are harder to hold than mice, and rats bite (!!!! it happens) more painfully). I have observed metabolic syndrome (diabetic neuropathy) in rats and mice, although my research (see Russian Wikipedia and here at RG) has not addressed metabolic syndrome.
Cortisol (!)-human, cat
Hydrocortisone (!) - rats, mice.
After vaccination (immunisation)(Escherichia coli, Proteus vulgaris) rats, death, experimental peritonitis, LD50 greater than LD50 without vaccination 7-9 times, and in mice - 2.5-4.0 times. ) in rats and mice, although my research (see Russian Wikipedia and here at WG) has not addressed metabolic syndrome.
Cortisol (!)-human, cat
Hydrocortisone (!) - rats, mice.
After vaccination (immunisation)(Escherichia coli, Proteus vulgaris) rats, death, experimental peritonitis, LD50 greater than LD50 without vaccination 7-9 times, and in mice - 2.5-4.0 times.
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