I had one mice dead after oral gavage a plant aqueous extract after 2 weeks. i don't know what is the problem.
Most complications due to oral gavage would occur in few days. However, there may be infection and sepsis in late days. Two weeks are quite long period for perforation or tracheal aspiration which will be symptomatic in first minutes-hours following the procedure. Also there may be an inflammatory reaction in oesophagus which may end in perforation. But for every situation, two week is a consideably long period.
we can classified oral gavage complications for two part:
1. early complications : aspiration, esophageal perforation, vasovagal shock, bleeding, nasopalate damage, ........
2. Pneumonia, esofaguteraceal fistula, , ......
Check if you are using a proper gavage needle. Some brands sell garage needles that they say are suitable for mice but that are too large to comfortably pass through their esophagus. I like this brand: https://www.finescience.com/en-US/Products/Animal-Accessories/Feeding-Needles
Besides, make sure you are correctly trained for the oral garage procedure with an experienced person or your local vet. One good hint is, obviously correctly hold the mouse during the garage, in a straight position, but at the same time not pressing their neck (or this will make it hard for the garage needle to go smoothly through). In a good garage procedure the needle goes effortlessly. If any mouse dies after oral gavage there must be an issue that needs to be solved.
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