Do not be too hard. This depends on the factor that you want to measure. For example, clotting factor VIII is heat sensitive and relatively short half-life.
In my opinion" 4 c "is suitable temperature and then immediately transfer the samples to -70 or liquid nitrogen.
for serum samples you can used Gel-clot activator tube that induce clot formation in 15 min RT , After clot formation, you can now centrifuges at 4 c .