Blood gas analysis and if going to select on anaesthetic parameters you will go for different anaesthesia parameters like physical, clinical and laboratory

Dear Sarhan Rashid Sarhan , nice topic of investigation! I'm a user of inhaled anesthetics. Volatiles have many aspects to evaluate... main are... pharmaco-kinetics & -dynamics. I believe you have to formulate your method according to the hypothesis of your research... animal model may be required. Clinical effectual experiments with therapeutical dosages are to be on the volunteers or selective patients. You may go through an old but interesting article of BJA. The Journal of Pharmacology and Experimental Therapeutics is quite useful in this regard. http://jpet.aspetjournals.org/content/349/1/21

- Rabiul

Greetings

From your question I am able to make out that you want to compare inhalational (volatile) anesthetic agents. In clinical practice, We need induction, maintenance, and recovery. Induction rapidity and smoothness is very important, so, you can measure/compare blood gas co-efficients or other similar physical properties. How fast the patient looses consciousness also can be measured. What concentration of expired agents corresponds to general anesthesia (can be suggested by BIS 40 -60) and how the cardiopulmonary system responds, especially the haemodynamics and compliance can also be assessed/compared. Similarly, recovery profile, how fast and smooth patients recovers can also be assessed. In post op, how the patient behaves; delirium, emergence profile can be compared. Additionally, if you are developing a newer agent, you need to assess the safety of the agent too, whether the drug causes any morbidity/mortality etc.

I hope this will help you.

If, you have any specific comparison/plan/objectives, you can share so that better opinions can be provided.