Would you please kindly read my manuscript the following one: Mizutani S, Naruse K, Hattori A et al. Physiological and pathophysiological

roles of placental aminopeptidase in maternal sera: possible

relation to preeclampsia and preterm delivery. Expert Opin Med Diagn

2009; 3: 479–491

I will mention several potential predictors of preeclampsia:

1. Human chorionic gonadotropin- has elevated values in the second trimester and may have predictive significance. Some authors believe that it is a consequence of abnormal placentation. Other authors consider that in conditions of hypoxia it comes to hyperplasia and hypersecretion of trophoblast.

2. Alpha feto protein- in the period 15-18 w.g. in preeclamptic pregnancies there is an unexplained increase of this marker.

3. Aktivin A, and especialy Inhibin A, in the same period (15-18 w.g), have increased values

4. The values of Human placental lactogen and Estradiol are lowest in preeclamptic pregnancies, but they  could be used to more to assess placental insufficiency and fetal endangerment.

Placental Growth Factor (PIGF) First trimester screening of PIGF allows early detection of women at risk for early onset pre-eclampsia before any clinical symptoms occur.

Dear Colleagues

I appreciate all your valuable comments and suggestions.

sincerely

Ehsan Saboory