In CFD of reacting flows, the low-Mach number formulation is often used in LES or DNS as the time-step requirement is much more relaxed compared to the full compressible formulation. In turn, this allows for the consideration of more complex kinetics, which can lead to better prediction of the flame itself and turbulence-flame interactions. However in return, the acoustics are neglected.

 Are the benefits of such simulations purely fundamental (i.e. better description of physical phenomena for various reasons?) For most of applications I can think off, either the incompressible assumption breaks down (i.e. piston engines, high speed flows) or the acoustic term is essential to ensure flame stability (jet combustion engine). 

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