I generally agree that p53-mediated repression is in most cases indirect through p21-E2F-RB (p107,p130) axis (we proposed that in our 2004 and 2005 papers) cited in this article. Still, I would not dismiss the possibility of isolated cases of direct repression in specific cell types. Such cell type-specific effects might require a cell type specific repressive co-factor.
Article The transcription factor p53: Not a repressor, solely an activator
Cell specific effects are quite specific and related to either inhibition or induction of physiological activities. However, cell type-specific genotoxic effects of intermittent extremely low-frequency electromagnetic fields and irradiation and radiofrequency generate different effects in different cell types. Due to presence of different receptors ,these exert differential effects depending on cell type. Few other examples are effects of the OAS/RNase L pathway on IFN induction in different cell types ,cell-Type-Specific Effects of Silibinin on Vitamin D-Induced, Cell type-specific effects of HDAC1 on stress vulnerability, hippocampal gene regulation and genome-wide acetylation landscape, Cell Type Specific Redox Status is Responsible for Diverse Electromagnetic Field, effects of simultaneous activation of both of these cell-type specific conductances within the atrial myocardium.The issue of adverse health effects of extremely low-frequency electromagnetic fields (ELF-EMFs) is highly controversial, Pathogenic Cell Type-Specific Effects in Alzheimer's Disease. 1 exerts direct neurotoxic effects while also inducing endoplasmic reticulum (ER) stres
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