There is an indication (J. H. Ali, W. B. Wang, M. Zevallos and R. R. Alfano, "Near infrared spectroscopy and imaging to probe differences in water content in normal and cancer human prostate tissues," Technol. Cancer Res. Treat. 3, 491-497 (2004)) that cancer tissues may have lower water content in vitro. I'm wondering if somebody done similar studies (in vitro, ex vivo, in vivo). While the prostate is of the main interest, any other organs and tissues would do it as well!
Slightly off track, but of possible interest (especially for references)
Chung et al. measured the binding state of water in breast cancer:
http://iopscience.iop.org/0031-9155/53/23/005
Srinivasan et al. discuss water in breast tissue
http://www.pnas.org/content/100/21/12349.short
r/
David
Hi Serge,
this is an interesting field. I can't help you with the prostate, however we investigated lung water content in vivo in rodents and human by microwave reflectometry. We found significant differences in tumour and lung tissue. It also changed after vessel clamping/ligation and during aventilation.
some links:
http://www.ncbi.nlm.nih.gov/pubmed/15503956
http://www.ncbi.nlm.nih.gov/pubmed/21172949
regards
Kai
David, Kai!
Many thanks, guys!! I knew that it should be more than Alfano's article, and I was right.
I may have few questions for you after reading the publications.
Regards,
Serge
I think cancer tissues may have more water content because their growth are very fast and more active, thus need more water for transferring of the electrolytes and other elements.
All references have turned out to be very useful. One of the references provided by David (Chung et al 2008) lists 5-6 references where a consistent increase in a fractional water content in breast tumors was demonstrated. Kai's article also shows a higher water content in lungs with tumor. While there might be a common mechanism in a way tumors affect concentrations of endogenous chromophores (oxy- and deoxy-hemoglobin, water...), more data on other organs would be needed to have a conclusive statement. Of course, there are some generalities in tumor growth mechanisms etc., still morphologies and functions of human organs and glands are different, and they may introduce subtle (or not so subtle?) deviations from the expected behavior (water content, to be specific). Again, this is merely my speculation due to lack of experimental data...
...Unless somebody would refer to some commonly accepted model that clearly outlines all the trends!
Water content as well as concentrations of Hb and HbO2 for a canine prostate ex vivo have been reported in the following publication:
https://www.researchgate.net/publication/262003897_Feasibility_of_interstitial_near-infrared_radiance_spectroscopy_platform_for_ex_vivo_canine_prostate_studies_optical_properties_extraction_hemoglobin_and_water_concentration_and_gold_nanoparticles_detection
Article Feasibility of interstitial near-infrared radiance spectrosc...
You may find the water content of tissue in the following publications:
White, D. R., Widdowson, E. M., Woodard, H. Q., & Dickerson, J. W. (1991). The composition of body tissues (II). Fetus to young adult. The British Journal of Radiology, 64(758), 149–59. Retrieved from http://bjr.birjournals.org/content/59/708/1209.short
White, D. R., Woodard, H. Q., & Hammond, S. M. (1987). Average soft-tissue and bone models for use in radiation dosimetry. The British Journal of Radiology, 60(717), 907–13. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/3664185
A study made on SCC of Head and Neck - ex vivo experiments (fresh surgical specimens): "Discrimination between Oral Cancer and Healthy Tissue Based on Water Content Determined by Raman Spectroscopy"
http://pubs.acs.org/doi/abs/10.1021/ac504362y
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