The distinction between True Experimental Designs and Randomized Control Trials lies in their specific methodologies and approaches to research. While both aim to establish causal relationships, True Experimental Designs typically involve the manipulation of an independent variable and the random assignment of participants to different groups. At the same time, Randomized Control Trials specifically focus on interventions or treatments applied to participants to evaluate their effectiveness. Understanding the nuances between these two approaches is crucial for researchers and practitioners in designing and interpreting research studies.