Could you tell me what the technical meanings of "LALA-PG" and "D665" in the name of Anti-Mouse CD28 (LALA-PG) Antibody (D665) (Cat.NO.: HY-P99123A) are? For example, does it involve antibody engineering modification markers (such as Fc segment mutation types) or clone numbers, epitope recognition codes, etc.?
Thanks for your answer!
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About the naming analysis of Anti-Mouse CD28 (LALA-PG) Antibody (D665):
1. LALA-PG:
Refers to the engineered modification of the Fc region of the antibody, specifically the combination of L234A/L235A double mutation (eliminating Fcγ receptor binding) and P331G single point mutation (reducing complement-dependent cytotoxicity), which aims to focus on the study of the antigen binding activity of the antibody by reducing the Fc effector function (such as ADCC/CDC effect).
2. D665:
It is the clone number of the monoclonal antibody, indicating that it is derived from a specific B cell clone. The clone number is used to uniquely identify the antigen recognition epitope and structural homogeneity of the antibody, ensuring the binding specificity and functional stability of the antibody under different batches of production or experimental conditions.
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