In PD research, the neurotoxin MPTP hydrochloride is often used to establish animal models. Its mechanism of action is: MPTP can pass through the blood-brain barrier and be metabolized into the active form MPP+ by monoamine oxidase B (MAO-B) in astrocytes. The latter enters dopaminergic neurons through the dopamine transporter (DAT), blocking mitochondrial electron transport chain complex I, ultimately leading to oxidative stress, mitochondrial damage and neuronal apoptosis, inducing Parkinson's-like symptoms.

It is worth noting that MPTP hydrochloride has been verified by MCE professional biological experiments and has been proven to successfully induce Parkinson's disease/Parkinson's syndrome models in C57BL/6N mice (relevant data provided by MCE professional technical team).

For further reference, please refer to the professional answers to the following frequently asked questions (FAQs) in the details page PDF:

1. Recommended mouse strains and ages;

2. Appropriate routes of administration;

3. Basis for dose selection;

4. Typical phenotypes of model mice;

5. Key detection indicators for successful modeling, etc.

Experiment Findings MPTP Effectively Induces Parkinson's Disease Model in Mouse.

The answer to this question comes from MCE Technical Support.

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