I have a grant that is pending IRB approval for a first-in-human, proof of concept study using microwires for intraspinal cord stimulation to restore standing and walking in humans. There is a nice review by Mushahwar on this concept in Journal of Neural engineering - see attachment

Thank you Dr. Konrad. We will review the information and give you our feedback asap.

Just some data from a mouse study, but the results were really intriguing. Treatment with naproxen improved recovery of motor function after SCI. Treatment with a hydrogen sulfide-releasing derivative of naproxen accelerated recovery or motor function much faster, and produced greater suppression of inflammation, expression of pro-inflammatory cytokines, etc.

See attached paper in FASEB Journal.

Thank you Dr. Wallace.

Though our institute which I head has been focused our study on SCI, but mainly on early cases. I have had an idea of early neurosurgery on spincal cord conctusion, its clinical application has resulted in fabulous result. If operated at 4-14 days after injury followed by 3 months of rehab., 70% of the patients could walk with a pair of crutches.

I have been studying the role of local estradiol synthesis in the central nervous system on the regulation of pain perception. I focused on specific SCI rat model. I did the unilateral electrolytic lesion of the spinothalamic tract (STT), this kind of lesion introduce Central Pain Syndrome (CPS) to the animal.

In my laboratory we are interested in the role of estradiol and aromatase, the enzyme that synthesizes estradiol, in the nervous system. We found that treatment with one dose of supra physiologic estradiol accelerated recovery. Also we investigated changes in the expression of aromatase and estrogen receptors in the spinal cord of rats following spinothalamic tract injury. We found an over expresion of aromatase enzyme in days 21 and 28 post surgery in the STT lesion group compared to sham group.

Thank you Mr. Samar. Initially, we are looking for treatments in a higher developmental stage. But we will consider your reasearch.

Read the article enough is enough" and be overcritical on their information.

We are beginning to study the application of Near Infrared LED, in lesions of the nervous system in animal models, as promente be a good therapeutic strategy, as it has proven anti-inflammatory, regenerative, analgesic and neuroprotective effects in different pathologies, but it is still necessary more basic research. Most of the effects are mediated at the mitochondrial level.

Thank you Dr. Soso. Initially, we are looking for treatments in a higher developmental stage. But we will consider your reasearch.