Ethylenediamine is attached to the surface of iron oxide nanoparticles via simple electrostatic interactions, what the effects of inhaling these nanoparticles may be? Pure ethylenediamine is toxic, would exert its toxicity for as long as the nanoparticles stay in the lungs or weak bond would be broken,leaving only the naked iron oxide nanoparticles? I need to check the safety factors of this particular SPION coated with this particular amine
Vincenzo Bortone
See my answer to your question
https://www.researchgate.net/post/Direct_coating_of_diamine_ethylenediamine_on_surface_of_Iron_oxide_Fe3O4?isAnswerFieldFocused=true
Is SPION toxic? There are plenty of biodegradable polymer to increase the solubility and biocompatibility of SPION.
I worked with PEG coated SPION. It reduces RES uptake and increases the circulation half life.
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