To simulate the lipid bilayer (10-10, 25-25 so on) from CHARMM-GUI membrane builder, we used to simulate it at various force field (AMBER14, AMBER03, AMBER14IPQ, AMBER15FB, NOVA, YAMBER) at water phase and gas phase.

But all of the case, the lipid bilayer broken down and form micelle within 1ns. How do we fixed it and run 100-200ns without breaking bilayer?

Thanks