Can anyone point me to a good summary of stability studies on Vitamin B12? I would like to learn about the difference of its individual biological forms regarding stability. (Light, PH, Temperature asf.)
Thank you!
David, you will find the best summary that I know of in Dr Bernard Krautler's chapter in the link below.
The other 2 references may be of incidental interest.
Kind regards, Carmen [Dr Carmen Wheatley].
[PDF] Organometallic chemistry of B12 coenzymes
B Kräutler - Metal ions in life sciences, 2009 - homepage.uibk.ac.at
Marcus AD, Stanley JL (1964) Stability of the cobalamin moiety in buffered aqueous solutions of hydroxocobalamin. J Pharm Sci 53:91–94. doi:10.1002/jps.2600530118 CrossRefGoogle Scholar
Adams JF, Ross SK, Mervyn L et al (1971) Absorption of cyanocobalamin, coenzyme B 12, methylcobalamin, and hydroxocobalamin at different dose levels. Scand J Gastroenterol 6:249–252. doi:10.3109/00365527109180702 CrossRefGoogle Scholar
The world of micronutrients still has many gaps, and the specific case of vitamin b12 is particularly complex given the clinical importance of its levels, which are low, but also high. In this sense, in complement to the debate question, I want to share with you the following manuscript detailing the aspects associated with high levels of vitamin b12.
Article Hipervitaminosis B12 una mirada desde la atención primaria
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