Specific inhibitors of FGFR4 for in vivo study?

Stanislovas S Jankauskas @Stanislovas_Jankauskas

11 November 2019 1 5K Report

Hi everyone!

I'm looking for commercially available specific inhibitors of FGFR4 to use in mice model. Either small molecule or antibody. I would appreciate if such compound have already been used in mice to have start-point for choosing a dose.

Thanks for your suggestion!

Charles D Anderson

Dear Dr. Jankauskas,

I came across these two,

1.)

Article Quantification of FGFR4 inhibitor BLU-554 in mouse plasma an...

FGFR4 inhibitor BLU-554 in mouse plasma

BLU-554 (>99%) was supplied by Carbosynth (Compton, Berkshire, UK).

2.)

H3B-6527

https://cancerres.aacrjournals.org/content/77/24/6999

https://www.selleckchem.com/products/h3b-6527.html?gclid=EAIaIQobChMIrrmwg4vq5QIVQl8NCh07MQZqEAAYASAAEgK3PfD_BwE

Best Wishes,

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