Hi everyone!
I am trying to replicate a clinically used solution (UW solution) in the lab which contains HES and am having some difficulty.
The HES is described as (5% HES with a molecular weight cutoff range of 100-1000 kDA and mean of 250 kDa). Does anybody know what type of HES this would be? hetastarch, pentastarch and where I could get some from? I have purchased some from Sigma but this is clearly the wrong stuff as it is insoluble in the volume required.
Many thanks
Tom Smith
Hi, Thomas...I am not quite sure if I am of help with this but I'll try: cf. attached pdf and find: ".....received HES infusions to improve microcirculation several months to 8 years prior to visiting our clinic. Most had received 6 % or 10 % hetastarch for 7 to 10 days." Perhaps this is the stuff you would get into the right percentage of solution? wish you good luck. Best regards, WM
Hi Wolfgang,
Thanks very much for your reply and citation, Do you know if this solution is based on 0.9% NaCl? if so unfortunately we wont be able to use it neat and we have not had much success with dialysis either in terms of generating large scale reproducible solutions...
BW and thanks again
Dear Thomas: just to inform: cf.
http://www.drugs.com/pro/hetastarch.html;
https://en.wikipedia.org/wiki/Hydroxyethyl_starch; the German Wikipedia (https://de.wikipedia.org/wiki/Hydroxyethylst%C3%A4rke) has included an information which I could find in the english version: "Die US-amerikanische Food and Drug Administration gab am 24. Juni 2013 eine Black-Box-Warnung für HES heraus.[3]" Reference 3= FDA Safety Communication: Boxed Warning on increased mortality and severe renal injury, and additional warning on risk of bleeding, for use of hydroxyethyl starch solutions in some settings = http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/ucm358271.htm;
http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/NewDrugApplicationsNDAs/UCM376787.pdf
http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/referrals/Hydroxyethyl_starch-containing_solutions/human_referral_prac_000012.jsp&mid=WC0b01ac05805c516f
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900092/
http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/NewDrugApplicationsNDAs/UCM083107.pdf
http://www.rxlist.com/voluven-drug.htm
Apologize...I don't like or want to tease you! I really do hope you'll find an answer. I unfortunately haven#t had the time to check the companies dealing with chemicals...
Regards WM.
Not at all, it is good information to have! Thankyou for your help Wolfgang:)
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