There is no need to dissolve the resin. One can record cp-MAS solid state NMR spectra

No access to solid state NMR

Dear Lynn,

I don't think that one can really dissolve a fully polymerized resin (as beads I assume?). Dissolution would mean destruction.

I guess you are interested in "something" conjugated to the surface on resin-beads or incorporated into them. Here HR-MAS is the normal NMR method (as pointed out by Sengottuvelan).

You may want to try to make a dense slurry of the beads (I'd propose in a solvent/mixture with [close to] identical density to inhibit phase-separation in the NMR tube). Dependent on the nucleus you wan't to observe you may be lucky to "see something" (see enclosed a file where we acquired 19F NMR on 50 mg's of densly packed synthesis beads in a DMSO slurry with a 19F carrying molecule conjugated. This was 32 scans in a 600 MHz cryoprobe).

You might also take a look here:

Article Resin Swelling in Mixed Solvents Analysed using Hansen Solub...

But these authors only investigated the disappearance (incorporation into the beads - making the NMR signals invisible) of the solvents in the slurry (swollen resin) to my understanding.

Melting (again I think this might be destructive) of the resin occurs at 205C...I know there are dedicated NMR probes for polymers allowing high temperature....but I do not know how high....

Good luck

Alfred