I am working with heterocyclic compounds for corrosion inhibitor. While working on weight loss study, final synthesis compound is not getting dissolved in 1N HCl, but it forms a suspension in 1 N HCl.
What can be done for solubility?
Or else any other solvent can be added?
Hi Ajit,
Hetrocyclic compound containing N-must be soluble in HCl solution, but if you have other hetro atoms you can try alcohols (Methanol,ethanol), acetone or DMSO. Good Luck
Thanks Salim sir for your precious comment but I have tried these solvents initially it is dissolved but after adding 1n hcl it's ppt reappears.
My compound products is equimolar reaction of Thiazole 2 amine with aldehyde derivatives like cinnamaldehyde it is soluble in Dmso but adding 1n hcl ppt reappears ...
Pls suggest possible action to resolve this problem if possible ...I am confused how it will work ...
Hi Ajit,
When your compound dissolve in a solvent ( make dilute solution if you want) then you can add IM HCl solution drop by drop tell your solution get little ( cloudy) then stop adding and use it ,you can not add more ppt will form. Good Luck
Dear salim sir,
Thanks for your valuable suggestion helped alot to me .Currently I am working in amanner briefed by you .Rest i share my progress to you soon.
Thanks
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