What do you want to simulate more specifically?

The question is, what aspects of Raman scattering due you want to simulate? Comsol, as a multiphysics software, is (in my understanding - haven't used comsol in quite a while) suited to calculate the focus fields, local field strength and aspects like SERS or TERS (by calculating plasmonic responses), as well as using the calculated fields and Raman tensors as an input to calculate the (polarization dependent) signal and its detection. This can be used to interpret signal contributions and optimize or understand the impact of your setup (focusing, polarization, plasmons,...).

If you are interested, however, in atomistic calculations, i.e. calculating Raman cross sections and the vibrational modes of molecules or crystals, you should look into some form of DFT or quantum chemistry software, because these aspect is not covered in COMSOL. In principle, such calculated properties could serve as input paramters for Comsol calcuations, e.g. as raman tensors.