Can any one suggest me what to do if controls in sub-population i.e. in one the gender, are not in Hardy Weinberg Equilibrium (HWE) in genetic association case control study? Which and how, the parameters must be adjusted for plausible results if is it so.
Thank you in anticipation.
Dear Adil Anwar,
I suggest you to see links in subject.
-A Goodness-of-fit test for Hardy-Weinberg Equilibrium in the Presence ...
https://www.universiteitleiden.nl/binaries/.../mi/.../mastermorra.pdf
-Basic statistics - PLINK 1.9 - cog-genomics.org
https://www.cog-genomics.org/plink/1.9/basic_stats
-A PRIMER ON ALLELIC ASSOCIATION
https://genepi.qimr.edu.au/staff/davidD/Course/HTML/part3.html
-How to Include Chromosome X in Your Genome‐Wide Association ...
https://onlinelibrary.wiley.com/doi/full/10.1002/gepi.21782
-Genotype Data Quality Assessment and Utilities — SNP & Variation ...
doc.goldenhelix.com/SVS/latest/.../genotype_data_quality.html
Best regards
Thank you Sir Mohamed-Mourad Lafifi for your response.
I could not open 1st, 3rd, and last link shared by you. Moreover, I am not working with sex chromosome. Further I would like to say that I am using SPSS already for my analysis.
Dear Adil Anwar,
For opening links you can used only title of link normally it must work. Also here are a complement of reference in topic.
-CRAN Packages By Name
https://cran.r-project.org/web/packages/available_packages_by_name.html
-Burroughs Wellcome Fund - ImmPort
www.immport.org/immport.../MM-HL-Adisease-version010.pdf;...
-Untitled - Springer Link
https://link.springer.com/content/pdf/10.1007%2F978-1-61779-555-8.pdf
-haplotype blocks and drug or alcohol dependence - Oxford Journals
https://academic.oup.com/hmg/article-pdf/15/6/807/.../ddl024.pdf
-Monday 19 Sep 12:15 -13:45 P.1.a Basic and clinical neuroscience ...
https://www.ecnp.eu/ecnp/print.aspx?confid=70&daypartid=99&dayid=202
Best regards
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