There is no easy answer to this question, and it's a matter of personal opinion to some extent, but I would like to hear thoughts from the RG community on aiming for several smaller papers versus one larger, more impressive paper.
I have been working on developing some bio-informatic tools for co-evolution analysis: I am actively working on applying these to a host of different projects.
I am considering submitting an Application note to the journal Bioinformatics, describing the software tools I developed, but I am unsure if I should hold them back to be featured in a paper that includes some biological discoveries.
For what it is worth, I am leaning towards publishing the smaller application note paper (2 pages). I am concerned with how this publication will be viewed on my CV, especially as weighed for employment, promotion, and grants (I am an Assistant Professor at a Community College).