Should I perform OGTT on normoglycaemic or TI and TII DM animals or both?

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Jaya Aseervatham

OGTT would be better, because it would give you the response of the animal to the drug

Vishnu Prabhakar Choudhari

Jaya thanks, my question is should I perform OGTT on normoglycaemic rat or TI DM and TII DM rats, Which is more appropirate?

Abhijeet P. Pandey

For new drug substance OGTT should be performed on alloxan monohydrate induced (intraperitoneal administration) diabetic rat.