The USA, Russia and China all interfere or have interfered with smaller states: USA in the Americas and Far East: Russia in Europe and Middle East: China on an economic and technical fashion and not yet military.
interference and non-interference can equally be seen as part of the humanist critique of war, whereby diplomacy dominated and state boundaries and rights were acknowledged. The Peace of Westphalia at the end of the Thirty Years War, based mainly but not entirely on religious disputes, established that no state had any right to interfere with another state's sovereignty or meddle in its internal affairs. While Machiavelli had proposed the 'the self preservation of the state with all means at any price'.
Great states require stasis and advantages for themselves, but often their interference creates problems and turbulence. Afghanistan, Vietnam, Hong Kong and perhaps soon offshore states. Do you agree?