Should a protein- protein interactome be constructed using only upregulated DEGs?

Bipasha Bhattacharjee @Bipasha-Bhattacharjee

24 July 2023 0 3K Report

I have a comparative transcriptome dataset, with a number of upregulated and downregulated genes. I want to construct a protein-protein interactome network to understand the node and hub genes and modules. Should just the upregulated DEGs be taken for the same or total?

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