The efficiency of the WHR Rankine cycle is dependent on the thermodynamic properties of the working fluid. R245fa (C3H3F5), water and ethanol were selected as three candidates from more than 30 working fluids reported in a literature review. Water was eliminated from the candidate list due to having a low condensation pressure (0.3 bar) leading to sealing concerns and a high freezing point. Ethanol has advantages over R245fa in reduced system pressure, volumetric flow rate through the expander and size of the recuperator. Higher system pressure has significant impact to the cost of the WHR system for mobile applications because the working fluid pump and the heat exchanger’s costs increase. Higher volumetric flow rates and comparatively lower pressure are desirable from a system perspective. The above mentioned considerations led to the selection of ethanol as a working fluid.