I used EdgeR to get the list of DEGs (differentially expressed genes) from my liver RNA-seq experiment. I have done the gene overrepresentation and GSEA based pathway analysis. I am currently taking one gene at a time and googling if someone has shown its role for something similar to my research topic. My question is, how do I filter important genes from unimportant ones (like olfactory receptors, immunology related, and predicted genes)? How do you guys do it? Please give valuable suggestions.

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