I often see papers show that during the rodent embryonic midbrain development, Lmx1a+ ventral midbrain regions (future midbrain DA neurons in the substantia nigra, ventral tegmental area and retrorubral field) are bordering Nkx2.2 (future oligodendrocytes or serotonergic neurons?) and Nkx6.2 (future motor neurons). Anyone have any idea of what brain structures Nkx2.2+ and Nkx6.2+ cells eventually become? I feel it's hard to link genetic studies with anatomical studies when it comes to ventral midbrain development.
Not necessarily. For example, Islet1+ populations in the ventral midbrain will eventually become ChAT+ neurons forming the oculomoter nuclei, which is the nuclei for the cranial nerve III, oculomoter nerve. I want to know that much of detail for other populations such as Nkx2.2+ cells, Nkx6.1+ cells, etc.
Nkx2.2 mostly give rise to a transient population of oligodendrocyte precursor cells. This is the case in the basal telencephalon or the spinal cord. And I said transient because they belong to the first wave of oligodendrogliogenesis and almost entirely dissapear/transform after the arrival of the second wave (PDGFR-alpha-positive OPCs).
Check These 2 papers might help you:
Prakash 2009 Development
Moreno-Bravo 2010 Developmental Dynamics
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