I am wondering if there are chronic disease conditions that exhibit pregnancy-induced physiological changes known to influence drug disposition during pregnancy. If such disease conditions, can such patients with such conditions be recruited to study the effect of pregnancy on the drug pharmacokinetics? In a similar vein, will the absence of a growing foetus reduce the ethical barriers that limit research in pregnancy?
I'm not aware of a chronic condition that exerts the same effects that pregnancy has on drug metabolism. However, the closest resemblance to pregnancy would be chronic inflammation. As you try to build a condition that is a proxy for pregnancy, you have to understand the mechanism by which pregnancy affects drug metabolism and the role of hormonal changes on expression of major drug metabolizing enzymes.
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