can any one give me the exact procedures for reduction of cyano groups into primary amine using aluminium hydride?
i know the general condition which are, reaction is performed in THF or diethyl ether, and must dry condition. water is added at the end to destroy the excess hydride.
what after complete the reaction? i cant obtain the product!
at the end should gives 2 layers since water and ether are not miscible. but it give me one layer !
i read somewhere that water and ether are miscible but in miscibility table they not.
If your target primary amine is fairly soluble in water, and if you started with a high concentration of your starting material, it is possible that your product is capable of bringing together the two liquids and preventing phase separation. (Remember that primary amines are good at hydrogen bonding.) You can try adding some saturated sodium chloride solution in order to "salt out" your product and force phase separation.
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