This your question might be 'classical stuff' (and is exhaustively deaklt with in most - if not all - handbooks of Histology and Histological Staining of (animal & human) tissues:
Simplified:
Just to think over:
'Stain' e.g. a fabric (consisting of two different 'matrices') with - simply - a dye solution: you'll get a fabric which might display ONE colour due to dyeing...= SIMPLE STAINING
You want to get an other tinge for the one or the other "matrix component" within your fabric: it needs another dye - perhaps with some intermediate steps ('reactants') to either wash out the "simple stain/dye) from the specific matrix compound while bound to the other one matrix component - and finally staining the second matrix component with the second dye: this might be called: DIFFERENTIAL STAINING..."
But - for scientific interpretation:
bother GOOGLE entering keywords/search phrase (only ONE possible way):
| Differential staining vs. simple staining dyeing |
and find/see: e.g. (out of some results):
(quote:)
A simple stain will generally make all of the organisms in a sample appear to be the same color, even if the sample contains more than one type of organism. In contrast, differential staining distinguishes organisms based on their interactions with multiple stains. (end of quote)
or (the whole text of the forementioned sentences:): https://surendranathcollege.ac.in/new/upload/AMAR_CHANDRA_DAS_GHOSHDifferential%20Staining2021-02-11Differential%20Staining.pdf