Purification of fluorescent labelled bisphosphonate ?

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Jack Silver

Those are very polar. I would consider ion exchange, and HILIC using silica or alumina with acetone, or acetonitrile as the organic solvent.

Gyanendra Prasad Panda

Jack Silver Thank you for your answer. I would like to know if we can do the purification of the above mentioned fluorescent labelled bisphosphonate using centrifugation ?

Do you mean centrifugal partition chromatography? Density gradient fractionation? Filtration with an ultracentrifuge?

Jack Silver filtration using ultra centrifuge or regular one

Gyanendra Prasad Panda Unless there are particles being removed, I don't see how that can work.

Jack Silver ok. I will look into it.Thank you for your time.