My brother has been admitted with massive left sided primary spontaneous pneumothorax which was properly managed by us with chest tube drainage with full expansion of underlying lung. We went for chemical pleurodesis in the form of povidone iodine but what I found is that there was 450 ml collection in the chest drain bag in the next 24 hours and which became nearly 15 ml in the next 24 hours. My question is how can we explain this 450 ml collection after pleurodesis indicated for primary spontaneous pneumothorax?