Separation of phthalhydrazide can be challenging. For these reasons, other methods for liberating the amine from the phthalimide have been developed.
The primary amines may also be liberated by reactions with 40% aqueous methylamine, n-pentylamine, Sodium Borohydride-2-propanol followed by acetic acid, and Sodium Sulfide in aqueous THF or acetone
Harsh reaction conditions: Reluxing with HCl or HBr affords the hydrochloric and hydrobromic salts.
https://www.organic-chemistry.org/protectivegroups/amino/phthalimides.htm
http://reag.paperplane.io/00002312.htm
Article Suggested Improved Method for the Ing‐Manske and Related Rea...
http://www.arkat-usa.org/get-file/18737/
Article An exceptionally mild deprotection of phthalimides
Phthalyl amidase selectively deprotects phthalimido groups under very mild aqueous conditions in a one-pot reaction to produce phthalic acid and the free amine.Article Selective Deprotection of Phthalyl Protected Amines
Your correct Jürgen Wintner, these conditions will work on peptides.
- Badges
- Science topic