How to make 50mM (or even higher concentration) tyrosine solution with pH around 7 for cell culture? Is it even possible? Right now I use T8566 from sigma or should I try another powder which is called ''L-tyrosine disodium salt dihydrate''?

I've search a lot of dicussion about this, and it can't be solved yet. It really made me feel so frustrated to do this...

I always use 1M HCl to reach higher solubility, and my working conc. is 10mM.

The problem is that when I try to adjust the pH at 50mM or 10mM, I always get a lot of precipitation…

Any suggestion will be appreciated. Please I really need some help!

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