Biodegradation is a unique and environmentally friendly process which is mediated by microbes but is sometime halted by the inhibitors like heavy metals. Hence, it is required to know that how inhibitors slow down or stop biodegradation?
The answer will be different for each bacteria-site (soil, water, air)-contaminant combination. For instance, some bacteria depending on the concentration the metal may be beneficial (i.e., co factors) others may be toxic. If you have a specific bacteria in mind, you might obtain a more specific answer.
Kindly look at; Microbial growth of hydrocarbons: terminal branching inhibits biodegradation;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC243570/
Biodegradability of all organic materials on the earth is possible
what matters is the rate of biodegradability
some are recalcitrant to bio-degradation
chain carbon compound it really difficult to break the chain like ligno-cellulose materials
i also agree with Jermith Oehek Masime
impaired CNP ratio can inhibit biodegradation, therefore supplementation of biodegradable nutrients to balance CNP ratio can enhance biodegradability of non-biodegradable compounds.
You can also have a look at the following overview where some major features and limitations of microbial bioremediation and phytoremediation are discussed: http://pac.iupac.org/publications/pac/pdf/2001/pdf/7307x1163.pdf
Biodegradation is catalysed by enzymes. So most of the times those hydrolytic enzymes were inhibited by metal inhibitors. So you should look the type of waste to be bioremediated, enzymes involved and possible inhibitors and can overcome by simpally chelating the metals which inhibits the enzymes.
Biodegradation of what compounds and under what conditions?
Is it aerobic process or anaerobic (sulfate reducing, nitrate -reducing or methanogenic conditions)?
Inhibitors of biodegradation of organic pollutants in both aerobic and anaerobic condition ?
An enzyme inhibitor is a molecule that binds to enzymes and decreases their activity.
Biodegradation or bioremediation is made possible by enzymes present in the microorganism. Once such an enzyme is inhibited the rate of biodegradation will also be affected.
There is no "generic" inhibitor. It depends on specific conditions on site. For instance, nitrate and nitrite can inhibit sulfate reducing and methanogenic degradation. Some compounds. such as aromatics or benzoate could be inhibitory at certain concentrations, etc.
The answer will be different for each bacteria-site (soil, water, air)-contaminant combination. For instance, some bacteria depending on the concentration the metal may be beneficial (i.e., co factors) others may be toxic. If you have a specific bacteria in mind, you might obtain a more specific answer.
I completely agree with the answer given by Dr. Teresa Cutright. You can grow pure bacteria and compare with bacterial consortium on specific medium having substrate and also various concentrations of same or different metal. You might get the result which you want.
Dear Guarav,
I strongly recommend you a book Molecular Microbiology of Heavy Metals'. It contains a lot of useful information on the mechanisms of tolerance or toxicicity of heavy metals to various microorganisms.
http://link.springer.com/book/10.1007%2F978-3-540-69771-8
inhibitors of bio degradation - slowing or prevention of a process of decomposition or destruction of products from Flora and fauna. These are natural processes mostly with microbial actions...
If you are monitoring degradation of compounds that involves ring cleavage you can try with 2,2’-Dipyridyl. it is a ring cleavage inhibitor.
Use of Natural products while it remnants disposed is BIO-degrable; while the derived products or Synthetic products are Non-biodegradable.
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