American society for apheresis (ASFA) has listed Dermatological diseases like Atopic dermatitis and Pemphigus vulgaris in category III. In these cases decision for plasmaphresis should be individualized depending on the patients' clinical scenario. Optimum response in these cases are not established. If I want to start therapy with plasmaphresis in a patient with Atopic dermatitis or Pemphigus vulgaris how many sessions of plasmaphresis have to perform to get a clinical response or to take a decision to abandon the procedure?