Has anyone seen toxicity due to doxycycline food in mice?

13 March 2024 1 5K Report

I am treating mice with doxycycline (75ppm) to induce gene expression but i see dermatitis in both control and transgenic mice.

Samir Ranjan Panda

Hi Erjola Rapushi

Yes, doxycycline toxicity has been observed in mice when administered in water and food.

Studies have shown that pregnant mice fed doxycycline in food exhibited placental abnormalities and impaired fetal development, especially at higher doses.

Article Perinatal exposure to tetracycline contributes to lasting de...

Article Revisiting doxycycline in pregnancy and early childhood - Ti...

Thanks,

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