Wheat production is severely hampered by the drought and heat stresses which generally coincides and augment the stress effect. It is difficult to remove the confounding effect of each stress on the other mainly in the field conditions. Although in irrigated areas, applying irrigation at the time of heat stress can control heat to a certain extent but in rainfed areas, there is no choice for timely irrigation. So, considering the depleting water table, the only solution seems feasible is to develop multi-stress (heat and drought) tolerant wheat cultivars. But it will require the focused effort to improve component traits related to photosynthesis and respiration. Which will be the most critical physiological traits that need to be targeted to combat both stresses together under predicted climate change? Can the heat-tolerant cultivars with a tendency (adaptation) to flower early morning and late evening to avoid heat stress can prove to be a game-changer?