You mean a complete new reactor setup.

Hi Omar, thanks for answering,

No. not a reactor.

I'm talking about a small scale powder melt compounder with an exit (extruder) into a thin film rolls. under 1mm thick.

and under phase 1 GMP QA system at the least

Refer to the XPlore website.

http://www.xplore-together.com/products/pharma-melt-extruder

https://www.k-online.de/vis-content/event-k2019/exh-k2019.2578073/K-2019-Xplore-Instruments-BV-Paper-k2019.2578073-CWBrvtBWTVGqfhV25A9IwQ.pdf

thanks Omkar

I have located 2 contacts in the US that can provide it (from an initial conversation) as a service

if relevant I can share once I know if that can really work.

Dear Yoni,

I would like only to share some information regarding your question. I was involved in the past in some R&D projects concerning encapsulation of API in biodegradable polymers by using the approach HME (hot melt-extrusion). For some experiences with small amount of materials (5-7 g) I have used the micro-compounder of ThermoFisher (Thermo Haake MiniLab2). More details about these equipments you can obtain via their web site.

Based on my experience, I will say that is not only a mixing of components, you need to arrive the optimal processing conditions and best formulations function of your objectives.

Success in your R&D project and good luck in doing the best choice,

Marius

Dear Yoni,

Here is the last variant of micro-compounder MiniLab3 of Thermofisher!

Best regards,

Marius

https://www.thermofisher.com/document-connect/document-connect.html?url=https%3A%2F%2Fassets.thermofisher.com%2FTFS-Assets%2FCAD%2FSpecification-Sheets%2FHAAKE-MiniLab-3-Product-Specifications.pdf&title=SEFBS0UgTWluaUxhYiAzIG1pY3JvLWNvbXBvdW5kZXI=

Marius Murariu could you let me know where you used this MiniLab3 and if they can provide compounding service? Appreciate.

Dear Richard,

The MiniLab 3 seems to be among the last variants of micro-compounders produced by Thermofisher !

In our laboratory we have a MiniLab 2 version (volume of mixing of 7 mL), but also other twin-screw extruders going from 15 mL (Xplore micro-compounders) to hundreds of grams, or many kilograms!

I do not have a confirmation that the suppliers of equipment could provide specific compounding services.

If you have the possibility to give me some details about your interest by sending me a message via RG, maybe I will be able to help you with some ideas or we can analyze the possibility to do some compounding services.

Best regards,

Marius

PS: Please take a look on the PPT sent by me!