Patient was diagnosed with acute refractory Ulcerative Colitis 4 years ago. Medications have not helped and thus patient is looking to alternative treatments. Patient reported, upon taking 3 grams of pharmaceutical grade Glycine supplement, number of daily bowel movements immediately reduced from 8 to 2 and bleeding reduced significantly. Has anyone else seen of or heard of such an impact with Glycine? What could be the therapeutic mechanism?
Hello,
More recent papers, e.g.:
Vidal-Lletjós, S., Beaumont, M., Tomé, D., Benamouzig, R., Blachier, F., & Lan, A. (2017). Dietary Protein and Amino Acid Supplementation in Inflammatory Bowel Disease Course: What Impact on the Colonic Mucosa?. Nutrients, 9(3), 310.
see p.9:
https://www.researchgate.net/profile/Annaig_Lan/publication/315509028
have referenced this older paper:
Tsune, I., Ikejima, K., Hirose, M., Yoshikawa, M., Enomoto, N., Takei, Y., & Sato, N. (2003). Dietary glycine prevents chemical-induced experimental colitis in the rat. Gastroenterology, 125(3), 775-785.
https://www.gastrojournal.org/article/S0016-5085(03)01067-9/fulltext
This is the RG link, but not full text:
https://www.researchgate.net/publication/10587563
Very best wishes,
Mary
Glycine prevent colitis by inhibiting induction of inflammatory cytokines and chemokines. It is postulated that glycine may be useful for the treatment of inflammatory bowel diseases as an immunomodulating nutrient.
Thank you both! Mary - I enjoyed your referenced papers! What are your thoughts on Glutathione for treatment of UC as briefly mentioned on that page 9? I have actually heard many good things on Glutathione as well but I haven't seen any studies to confirm.
Glycine is an amino acid, a building block for protein. It is not considered an "essential amino acid" because the body can make it from other chemicals.
Applying cream containing glycine and other amino acids seems to reduce pain and slightly improve the healing of leg ulcers. Analogue, glycine hepls for healing of erosions and ulcers in the colon.
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