Pathological Effects of Lead ?

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3T3-L1 cells not differentiating ?

Hi, I have been working with 3T3-L1 cells for over a year now.However, over the last couple of months they stopped differentiating into adipocytes. I seed at 200k cells/well (12 well plate), and...

23 May 2024 3,356 1 View

Transfection of MDA MB 231 with miRNA mimic using lipofectamin 2000 ?

What is the optimum concentration to be used for the miRNA mimic and if there is a good working protocol please advice

17 December 2023 5,683 0 View

PCR non-specific binding?

Hi, I have a PCR product for DDL gene for Enterococcus faecalis with non-specific binding as appears in the gel every time I run a gel for the positive control I see two bands the first is my band...

29 October 2023 1,315 3 View

Overload mark on the amplifier multiclamp 700B ?

I use molecular devices setup to patch acute brain slices, and I face this problem of "overloaded"sign that appears on the amplifier, and even when I try to autocomponsate the pipette it shifts to...

09 August 2023 4,032 3 View

Is it possible to perform KEGG pathway analysis with genes without corresponding ENTREZ ID?

Some genes that resulted from my differential gene expression analysis don't have corresponding ENTREZ ID and I want to perform KEGG pathway analysis but most tutorials analyze data with no...

24 July 2023 3,961 2 View

Hello, is it permissible to use only four rats in each group in the experiment design??

What is the minimum number of animals in each group used in expermint?

09 July 2023 5,390 3 View

Can we put a mebrane above the surface of the dura of brain of rats?

I think of applying the drug as a continuous infusion over 36 hours. I thought of putting it on a bio-compatible membrane over the surface of the brain is this possible? has anyone seen a study...

26 April 2023 8,612 0 View

Do anyone have an idea about why my PCR doesnt work ..and how to tackle this issue?

Hi everyone, I have a problem with my PCR and tried so many trials to get my product..I am working on RAG 1 gene in birds...my PCR doesnt work at all..however..I used many recipes and programs to...

27 October 2022 6,814 3 View

I am recently using schrödinger software. I need help to use Espresso with nanopartciles- ligands. Can I find an expert here?

I am following the examples from Schrödinger software but I still face difficulties. It would be nice if I can get help here.

19 May 2022 2,607 0 View

If there any open source (program) to plot the Nanopartciles and attach ligands. From such structure I would like to calculate the DFT?

Dears, If there any open source (program) to plot the Nanopartciles and attach ligands. From such structure I would like to calculate the DFT? kind regards

23 March 2022 3,510 5 View

For an in-vitro drug release study, what molecular weight cut-off (MWCO) dialysis bag is required for a 117 kDa protein?

kindly reply me. Thanking you in advance.

05 August 2024 7,727 4 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

19 July 2024 8,522 0 View

How to extract binding energy from pv.maegz file without using Schrodinger?

I have conducted virtual screening using Schrödinger on a database of 17,000 molecules. Unfortunately, I cannot use the system with the Schrödinger license at the moment. I am trying to find a way...

18 July 2024 2,881 4 View

Use of NC or NTC to descibe negative control?

Hello, I would like to ask which is the best terminology to use for describing a negative control in an experiment (drug testing in-vitro, viral infection): NC (negative control) or NTC? Thank you...

18 July 2024 4,183 2 View

What is the suitable solvent of MIL-100 for chemotherapy?

I synthesised a nanocarrier by conjugation MOF (MIL-100) with folic acid for use in chemotherapy but the samples didn't dissolve completely in aqueous solution or DMSO. Instead, they only...

15 July 2024 2,414 1 View

How to calculate percentage cumulative drug release?

How to calculate percentage cumulative drug release when, Total volume of dissolution media = 250ml Added formulation was equivalent to 10mg of drug Sample withdrawn = 1ml each time Sink condition...

15 July 2024 4,192 1 View

Abnormal data in in-vitro drug release study?

I'm doing in-vitro drug release study using dialysis bag method and collecting samples from the external medium at several time points, subjecting to UV-Vis spectrophotometry. But my absorbance...

14 July 2024 6,829 2 View

Does Fentanyl presence in injecting drug user communities require special harm reduction measures?

With Fentanyl already being detected in some countries in Europe, I believe many of us are not educated enough on special needs of injection drug users that use Fentanyl, due to its high strength...

08 July 2024 7,694 3 View

What are the trending topic to writ e a review article on it?

The topic should relate to pharmacy ,drug, methos of drug discovery, or any other topic but related to dug or pharmaceutical field

02 July 2024 4,031 3 View

Muthanna Hadi Hussain

I think you should ask Dr. Khaleel...

Alaa AbdulAziz Abed

In chickens, paleness, enlargement and fatty changes of liverand infiltration of inflammatory cells with necrosis of hepatocytes and loss of normal architecture , kidneys shown haemorrhage and atrophy and increased the space in glomuruli along with degeneration and necrosis of tubular epithelium

Khalil Al-Nailey

https://www.britannica.com/science/lead-poisoning

Ali hadi Ghawi

Good subject

Zahira Abduljabbar Abdulameer Al-Zuhairi

Qassim Kshash

Dear Dr.Shiammaa

Kindly check here

https://www.ncbi.nlm.nih.gov/pubmed/4349348

Thanks

Arvind Singh

Please have a look at these PDF attachments.

Noor Idan Jarad

hi https://www.ncbi.nlm.nih.gov/labs/articles/4349348/