Could someone tell me what is the minimum size described for a passive accumulation of nanoparticles in a brain tumor? Could you please recommend me any article?
However, in all those works, the authors linked the nanoparticles to some targeting agent such as SynB peptide or Epidermal Growth Factor, in order to overcome the blood brain barrier; or in the works the authors only use an "in vitro" aproximation.
I am looking for the critical size without using targeting agent or delivery agent.