The PhD Thesis in the link below could prove interesting for your case. An MPC controller is applied based on a thermal model (the neural network as discussed above will work too, but it is interesting to use physical knowledge about heat transfer processes in a building for optimal control).
Every human being behave differently from the other. This is a well known fact. But you as a design engineer should think of how to minimize energy consumption in a building you design. In this regard I refer you to read the chapters on : Building Operation and Maintenance published in the volume of HVAC Applicatios which is published by ASHRAE every 4 years.