After the cells are transplanted in the injury site, they begin to regenerate nerve fibres across the damaged region of the spinal cord.
This allows the dogs to slowly, but surely regain the ability of their motor cortices to communicate with their back legs.
What are the cells responsible for this movement of paralyzed legs of a dogs?
What is the mechanism present behind this cells to restore legs movement?
This is a case of nerve regeneration, where the affected part of the body is able to repair damaged nerve connections. Although the recovery and the time needed to restore the functions of the affected part depends upon the amount of damage caused to the nerve network. However, the emergence of regenerative medicine and stem cells the chances of recovering of paralysed parts post traumatic injuries have been greatly enhanced.
In the current case the cells used from nasal area have a rich supply of nervous tissue, which includes neuroblast cells and schwann cells. Both have proven potential of nerve regeneration and re-myelination. When they are transplanted to the site of injury which has almost no active nerve network or have decayed remains of the network. The transplanted cells divide and re-establish and revive the network thus restoring the function of the affected area.
The actual healing and regenrative process is much more complex, which includes, nerve regeneration as well as re-vascularization of injured area.
This kind of work is being extensivly carried out on mouse and other animal models. The following link decribes the use of earthworm in the tradition chinese medicine for regenerative therepeutic purposes:
http://www.hindawi.com/journals/ecam/2011/380809/
http://www.adelsonfoundation.org/nrrfc.html
The above link will enable you to understand the kind of work being carried out in regenerative and rehablitative medicine.
What is the present status of regenerative medicines in humans?
How this type of medicines will help for humans?
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