Stating that the photosensitizer effects have two types. 1) Direct effect 2) In-direct effect.
I am interested to know if there is a photosensitizer that is generating substantial damage by PDT type 1 without relying on oxygen. I want to use this molecule for studying DNA damage in a hypoxic effect on the microscope.
As far as energy is concerned, PDT is a potentiation of the oxydative power of oxgen by light. The initiation step is folowed by the chain raction of peroxide. The hypoxic state will strongly reduce the efficiency of PDT. By the way many cancers tumor are in an hypoxic state. You may have a look to photo-initiators for UV-glue and photolithography. These photo initiators relay less on oxygen since the chaine reaction by the monomers provide the energy of the process.
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